PO-03-097 DEFINING ELECTRODE CONFIGURATION FOR MAPPING MICROANATOMIC REENTRIES SUSTAINING ATRIAL FIBRILLATION

A major challenge in mapping atrial fibrillation (AF) to guide ablation is that it unclear what resolution required map potential regions of interest such as those microanatomic reentries revealed by optical ex-vivo human hearts (fig. A). The goal the study was define electrode configurations can identify targets specific EGM traces generated during conduction through common path AF reentry. We simulated a reentry sustaining anisotropic 3D model tissue 40x40x3 mm with an endocardial pectinate muscle 3x3x15 (0.25 resolution, fig. B), using Koivumäki-cellular action potential. simulation also included recordings unipolar and bipolar electrodes (3 inter-electrode distance, 1 length, 2 diameter) different distances orientations from B). Local activation time C) showed sub-endocardial reentry, cycle length 110 ms. electrical wall below (Fig. D) compared at E). On EGMs close (<2mm) activity reentrant be identified both signals peak amplitude similar or larger than main (figs E-F). When were perpendicular muscle, lower 25% amplitude. Our suggested distance detect should < 4mm. Mapping more reproducible for mapping, highly sensitive orientation relative conduction.